Objectives: This study examined factors associated with oral health and stress in South Korean adolescents using data from the 20th Youth Online Health Behavior Survey, including a total of 54,653 subjects. Methods: General characteristics, oral health behaviors, and stress related to oral symptom experiences were analyzed using the complex sample chi-square test. Factors influencing stress were identified through complex sample logistic regression analysis. Results: Regardingfactors affecting stress, compared with adolescents who brushed their teeth thrice the previous day, stress levels were 1.28 times higher (p<0.001) for those who brushed once or less, and 1.07 times higher (p<0.05) for those who brushed twice. Stress was 0.73 times lower in cases without pain (p<0.001), 0.79 times lower in cases without tingling & throbbing (p<0.001), and 0.71 times cases in those without gingival bleeding (p<0.001). Conclusions: These results indicate a strong association between oral health and stress among adolescents. The results provide foundational data for developing preventive strategies and practical educational programs aimed at promoting oral health in this population.