Objectives: This study examined the association between oral care problems, oral care practices, and oral health evaluation among adults with cardio-cerebrovascular disease. Methods: In this descriptive study, data from a structured questionnaire of 135 adults who visited medical institutions in Busan between January and March 2025, were analyzed. Statistical analyses were performed using IBM SPSS Statistics 29.0, at a significance level of p<0.05. Results: A higher level of oral care problems was significantly associated with lower oral care practice (r=−0.219, p<0.05) and higher oral health evaluation (r=0.634, p<0.001) scores. Multiple regression analysis showed that the level of oral care problems (β=0.496, p<0.001) was a strong predictor of oral health evaluation, while oral care practice (β=−0.184, p<0.01) was associated with improved oral health evaluation scores. Conclusions: These findings suggest a close association between the level of oral care problems and oral health evaluation among adults with cardio-cerebrovascular disease, highlighting the need for tailored oral health management and intervention programs.